Data on cancer that emphasize the impact of this disease on older persons i
n the context of an expanding aging population in the United States is desc
ribed using population-based statistics on incidence and mortality. Sixty p
ercent of all incident cancers and 70% of all cancer mortality occur in peo
ple 65 years and older. A combined cancer and aging epiemiologic perspectiv
e of the cancer burden for the elderly is given, providing a backdrop for t
he articles in this issue. There is an urgent need for special attention to
older persons as a target group for the integration of aging and cancer re
search. A discussion on pertinent clinical issues and questions that should
be considered in treatment of cancer in the elderly is also provided.