Preparative monolithic silica sorbents (PrepRODs (TM)) and their use in preparative liquid chromatography

The use of monolithic silica sorbents for the isolation of substances by pr eparative liquid chromatography is demonstrated. Preparative liquid chromat ography is recognized as a valuable technique for the isolation and purific ation of substances in the pharmaceutical and fine chemicals industry. The system technology has meanwhile reached a high standard, and the greatest f uture improvements are expected to arise from new and improved adsorbents. Monolithic silica sorbents offer some unique features for preparative liqui d chromatography. They exhibit high efficiencies even at high now rates due to their fast convective mass transfer and can therefore be used at very h igh mobile phase velocities. Leading to high productivity and hence to maxi mum process economy. The benefits of this new type of adsorbent are illustr ated for an example in batch-chromatographic mode and an example using the continuous simulated moving bed (SMB) technology.