Serum and lung levels of thiamphenicol after administration of its glycinate N-acetylcysteinate ester in experimentally infected guinea pigs

Thiamphenicol is an analogue of chloramphenicol and is characterised by a b road spectrum of action. In this study, serum and lung levels of thiampheni col (TAP) were studied in infected guinea pigs after the administration of thiamphenicol glycinate N-acetylcysteinate (TGA). Animals received a single dose of TGA (lj mg/kg, subcutaneously) immediately after intra-tracheal in fection with Haemophilus influenzae (about 10(7) CFU/animal). Serum and lun g concentrations of TAP were determined at 0. 1, 3. 6, 12 and 24 h after dr ug administration by means of HPLC. TAP serum levels were elevated at 1 h a nd remained detectable for 24 h after dl up administration. Tissue lung lev els were comparable to peak serum concentrations but remained higher and de creased more slowly than serum concentrations. (C) 2000 Elsevier Science B. V. and International Society of Chemotherapy. All rights reserved.