Adenosine with cold blood cardioplegia during coronary revascularization

Objective: To investigate whether adenosine in association with blood cardi oplegia results in more rapid cardiac arrest or improved myocardial protect ion. Design: A prospective, randomized, placebo-controlled double-blind clinical study, Setting: Operative and intensive care units in a university hospital, Finla nd. Participants: Forty patients undergoing primary, elective coronary revascul arization. Intervention: Adenosine as a bolus dose, 12 mg intravenously, was given imm ediately before the induction of blood cardioplegia. Measurements and Main Results: There were nonsignificantly higher serial se rum values of CK (MB) (p = 0.33), troponin-T (p = 0.23), and troponin-I (p = 0.10) in the adenosine group, There were no differences between the group s in arrest time, blood pressure decrease, or lactate extraction. Conclusions: The adenosine regimen used in this study did not cause more ra pid arrest with blood cardioplegia, The effect on cardioprotection was insi gnificant. Copyright (C) 2000 by W.B. Saunders Company.