This cross-sectional study examined the validity of the conduct disorder hy
pothesis of adolescent drug involvement, largely tested to date on normal p
opulations, on a large drug clinic-referred sample (N = 2582). All subjects
met DSM-III-R criteria for either abuse or dependence of at least one psyc
hoactive substance. Based on self-report data from the Personal Experience
Inventory (PEI) (Winters & Henly, 1989), multiple regression analyses were
conducted to predict prior twelve months drug use frequency from psychosoci
al risk variables. It was hypothesized that the Delinquency factor would ac
count for the most variance in drug use compared to three competing factors
(Psychological Distress, Nonconventional Values, and Family Distress). The
analyses provided support for the hypothesis across gender, age and ethnic
groups. The Delinquency factor uniquely accounted for about 50%-60% of the
variance in drug use severity. Backward deletion regression analysis of in
dividual scales indicated that Peer Chemical Environment and Deviant Behavi
or (both part of the Delinquency block) and, to a lesser degree, Psychologi
cal Disturbance (part of the Psychological Distress block), were consistent
ly the most predictive of drug use. The findings are seen as consistent wit
h the viewpoint that delinquency behaviors are important mediators of adole
scent drug abuse and, thus, they merit central attention in prevention prog
rams. The continuing need to develop and test theories about the pathways t
o drug involvement pertinent to severe-end, clinic-referred adolescents is
discussed.