Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients

Authors
Gieffers, J Reusche, E Solbach, W Maass, M
Citation
J. Gieffers et al., Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients, J CLIN MICR, 38(2), 2000, pp. 881-882
Citations number
10
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN journal
00951137 → ACNP
Volume
38
Issue
2
Year of publication
2000
Pages
881 - 882
Database
ISI
SICI code
0095-1137(200002)38:2<881:FTDCPI>2.0.ZU;2-R
Abstract
A recent North American study detected Chlamydia pneumoniae in 17 of 19 bra ins of Alzheimer's patients and supposed a C. pneumoniae infection to be a risk factor for Alzheimer's disease (AD). In this study, we analyzed paraff in-embedded tissue samples of 20 AD patients by nested PCR and immunocytoch emistry with a panel of antichlamydial antibodies and could detect neither C. pneumoniae-specific DNA nor chlamydial antigens; From our data, the pres ence of C. pneumoniae in the brains of Alzheimer's patients is not a common phenomenon; an association remains questionable.