Parental psychopathology and reports of the childhood home environment in adults with early-onset dysthymic disorder

In previous studies, patients with dysthymic disorder (DD) have reported si gnificantly more adverse early home environments than patients with episodi c major depressive disorder (MDD) and normal controls. However, DD is also associated with increased rates of mood and personality disorders in first- degreee relatives, raising the possibility that the DD-early adversity rela tionship may be due to the confounding effects of parental psychopathology. The present study addressed this issue using a sample of 97 adult outpatie nts with early-onset DD, 45 adult outpatients with episodic MDD, and 45 nor mal controls, and their first-degree relatives. The early home environment was assessed with semi-structured interviews and self-report inventories. P arental psychopathology was assessed using semi-structured direct and famil y history interviews, and diagnoses were assigned using the best-estimate p rocedure. Results indicated that parental mood and personality disorders we re strongly associated with probands' reports of early adversity. However, patients with DD continued to differ significantly from patients with episo dic MDD and normal controls after controlling for parental psychopathology.