Obesity is among the most important medical problems in America today. Curr
ently, similar to 1 in 4 children and 1 in 2 adults are overweight, prevale
nce rates that have increased by 50% since the 1960s. In an attempt to comb
at this problem, the Federal government and various official medical agenci
es have advocated decreasing intake of total fat acid sugar, while increasi
ng consumption of "complex carbohydrate." Despite a recent reduction in fat
consumption to near the recommended 30% of total energy, rates of obesity
have continued to rise, suggesting that other dietary factors may play a cr
itical role in body weight regulation. One such factor may be glycemic inde
x. This review examines the physiologic effects of glycemic index and argue
s for the need for controlled clinical trials of a low glycemic index diet
in the treatment of obesity.