Drug-induced linear IgA bullous dermatosis after vancomycin discontinuancein a patient with renal insufficiency

Linear IgA bullous dermatosis (LABD) is an autoimmune, subepidermal, vesicu lobullous disease that has been commonly associated with the use of vancomy cin hydrochloride. Lesions typically appear during vancomycin therapy, 24 h ours to 15 days after the first dose. A 65-year-old white man with renal in sufficiency developed pruritic, tense bullae on the right chest, right medi al arm, right flank, abdomen, and right upper thigh 14 days after his last dose of vancomycin. Histopathologic examination and immunofluorescence stud ies were diagnostic of LABD. Vancomycin-related LABD may appear as long as 2 weeks after the drug is discontinued.