Acanthamoeba is a recognized pathogen in the immunocompromised patient, com
monly presenting as chronic or subacute encephalitis. However, cutaneous di
sease in the absence of CNS involvement is increasingly recognized, especia
lly in the setting of chronic, nonhealing skin lesions in the patient with
AIDS. We describe a patient with AIDS and cutaneous acanthamoebiasis and re
view our experience with treatment and diagnosis.