The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas

Authors
Rajan, L Broussard, D Lozano, M Lee, CG Kozak, CA Dudley, JP
Citation
L. Rajan et al., The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas, J VIROLOGY, 74(5), 2000, pp. 2466-2471
Citations number
38
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
74
Issue
5
Year of publication
2000
Pages
2466 - 2471
Database
ISI
SICI code
0022-538X(200003)74:5<2466:TCLIAC>2.0.ZU;2-4
Abstract
Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias . TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tes ted, whereas 80% of the tumors showed c-myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7) may cause c-my c overexpression by cis-acting effects at a distance.