Background: Esophageal perforations are the most frequent complications of
endoscopy of the upper gastrointestinal tract. Life-threatening consequence
s such as mediastinitis, septic disease, or multiple organ failure are poss
ible. Traditional surgical and conservative methods of treatment should be
distinguished. In serious cases, thoracotomy in particular is a high-risk o
peration. Patients and Results: This case demonstrates the successful endos
copic treatment of an esophageal perforation with mediastinal empyema by fi
brin gluing. Conclusions: Esophageal perforations up to 20 cm aboral and a
maximum diameter of 1.5 cm could be treated by rigid endoscopical fibrin gl
uing. High-risk patients could be managed effectively avoiding extensive su
rgery.