The effects of low frequency and two-pulse stimulation protocols on synaptic transmission in the CA1-subiculum pathway in the anaesthetized rat

Authors
Anderson, M Commins, S O'Mara, SM
Citation
M. Anderson et al., The effects of low frequency and two-pulse stimulation protocols on synaptic transmission in the CA1-subiculum pathway in the anaesthetized rat, NEUROSCI L, 279(3), 2000, pp. 181-184
Citations number
19
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
279
Issue
3
Year of publication
2000
Pages
181 - 184
Database
ISI
SICI code
0304-3940(20000204)279:3<181:TEOLFA>2.0.ZU;2-9
Abstract
The downregulation of synaptic efficacy is referred to as long-term depress ion (LTD). Recent work has shown that a two-pulse stimulation (TPS) protoco l is successful at inducing LTD in vivo in area CA1 of the hippocampus. Her e, we examine the ability of two TPS protocols and two low-frequency stimul ation (LFS) protocols to induce LTD in the projection from hippocampal area CA1 to the subiculum in the anaesthetized rat. We find no evidence of LTD induction with TPS or LFS protocols. Instead, with three of the protocols ( both TPS protocols and 1 Hz LFS), a late-developing potentiation is observe d. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.