New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures

[GRAPHICS] We present two new diffusion edited NMR experiments, improved DECODES and H ETDECODES, that sort the constituents in a mixture by their individual diff usion coefficients. These experiments should allow the partial NMR spectral assignment and cursory structure elucidation of compounds in a complex mix ture as an aid in the dereplication of known or nuisance compounds.