Organ-specific manifestations of HIV disease in children

With the development of sensitive screening assays to more adequately prote ct blood supply, perinatal (mother-to-infant) transmissions of the virus ha s become the most commonly reported HIV transmission risk for children. The shift in transmission risk means that the immature immune systems and deve loping and growing organs of fetuses and infants are affected by HIV infect ion. Perinatal HIV infection has unique features that are not commonly repo rted in adult hosts. This article reviews the organ-specific manifestations of perinatally acquired HIV infection.