Central nervous system manifestations of an ibuprofen overdose reversed bynaloxone

Ibuprofen overdose is usually characterized by GI upset, dizziness, and mil d sedation. On rare occasions, severe complications such as respiratory fai lure, metabolic acidosis, renal failure, coma, and death have been reported in both adults and children. Presently, treatment of acute ibuprofen intox ication with complications requires supportive therapy until the symptoms r esolve over 24 to 48 hours. We report the case of an 11-month-old female in fant with a depressed level of consciousness after ingestion of ibuprofen w hose mental status markedly improved with administration of naloxone.