Rt. Brouillette et al., Nocturnal pulse oximetry as an abbreviated testing modality for pediatric obstructive sleep apnea, PEDIATRICS, 105(2), 2000, pp. 405-412
Objective. To determine the utility of pulse oximetry for diagnosis of obst
ructive sleep apnea (OSA) in children.
Methods. We performed a cross-sectional study of 349 patients referred to a
pediatric sleep laboratory for possible OSA. A mixed/obstructive apnea/hyp
opnea index (MOAHI) greater than or equal to 1 on nocturnal polysomnography
(PSG) defined OSA. A sleep laboratory physician read nocturnal oximetry tr
end and event graphs, blinded to clinical and polysomnographic results. Lik
elihood ratios were used to determine the change in probability of having O
SA before and after oximetry results were known.
Results. Of 349 patients, 210 (60%) had OSA as defined polysomnographically
. Oximetry trend graphs were classified as positive for OSA in 93 and negat
ive or inconclusive in 256 patients. Of the 93 oximetry results read as pos
itive, PSG confirmed OSA in 90 patients. A positive oximetry trend graph ha
d a likelihood ratio of 19.4, increasing the probability of having OSA from
60% to 97%. The median MOAHI of children with a positive oximetry result w
as 16.4 (7.5, 30.2). The 3 false-positive oximetry results were all in the
subgroup of 92 children who had diagnoses other than adenotonsillar hypertr
ophy that might have affected breathing during sleep. A negative or inconcl
usive oximetry result had a likelihood ratio of .58, decreasing the probabi
lity of having OSA from 60% to 47%. Interobserver reliability for oximetry
readings was very good to excellent (kappa = .80).
Conclusions. In the setting of a child suspected of having OSA, a positive
nocturnal oximetry trend graph has at least a 97% positive predictive value
. Oximetry could: 1) be the definitive diagnostic test for straightforward
OSA attributable to adenotonsillar hypertrophy in children older than 12 mo
nths of age, or 2) quickly and inexpensively identify children with a histo
ry suggesting sleep-disordered breathing who would require PSG to elucidate
the type and severity. A negative oximetry result cannot be used to rule o
ut OSA.