Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice

This study was designed to investigate the effects of synthetic mouse pancr eatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroven tricular (ICV) injection of mPP (0.003-3 nmol) dose-dependently increased f ood intake. A significant increase was observed 20 min after ICV injection and continued for 4 h, The intraperitoneal (IP) injection of mPP (0.03-30 n mol) dose-dependently decreased food intake. A significant decreases was ob served 20 min after IP injection and continued for 4 h, In the elevated plu s maze test, the ICV injection of mPP (0.003-3 nmol) did not affect anxiety behavior. These results suggest that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice. (C) 1999 Elsevier Science Inc. All rights reserved.