Melanin-concentrating hormone (MCH) modifies memory retention in rats

Authors
Monzon, ME de Souza, MM Izquierdo, LA Izquierdo, I Barros, DM de Barioglio, SR
Citation
Me. Monzon et al., Melanin-concentrating hormone (MCH) modifies memory retention in rats, PEPTIDES, 20(12), 1999, pp. 1517-1519
Citations number
16
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
20
Issue
12
Year of publication
1999
Pages
1517 - 1519
Database
ISI
SICI code
0196-9781(199912)20:12<1517:MH(MMR>2.0.ZU;2-1
Abstract
The purpose of the present study was to evaluate the possible effect of mel anin-concentrating hormone (MCH) on learning and memory by using the One-tr ial step-down inhibitory avoidance test in rats. The peptide was infused in to hippocampus, amygdala, and entorhinal cortex. MCH caused retrograde faci litation when given at 0 or 4 h post-training into hippocampus, but only at 0 h into amygdala. From these results, it seems that MCH modulates memory early after training by acting On both the amygdala and hippocampus and, 4 h after training, on the hippocampus. (C) 1999 Elsevier Science Inc. All ri ghts reserved.