Preliminary clinical investigation of the contraceptive efficacy and chemical pathological effects of RICOM-1013-J of Ricinus communis var minor on women volunteers
Co. Isichei et al., Preliminary clinical investigation of the contraceptive efficacy and chemical pathological effects of RICOM-1013-J of Ricinus communis var minor on women volunteers, PHYTOTHER R, 14(1), 2000, pp. 40-42
The seeds of Ricinus communis Linn, RICOM-1013-J, administered as a single
oral dose of 2.3-2.5 g once per 12 months protected against pregnancy in 50
women volunteers for a period of one year. The antifertility and contracep
tive efficacy of the seed was demonstrated in this study. Clinical observat
ion revealed very minimal side effects. Some of the side effects investigat
ed included headache, nausea, vomiting, weight gain, loss of appetite, rais
ed blood pressure and dysmenorrhoea. Furthermore, both the renal and liver
functions were not affected as revealed by urea, electrolyte and creatinine
values as well as total bilirubin, conjugated bilirubin, serum albumin, to
tal protein and transaminases values when compared with control values. In
addition cholesterol and phospholipids were not significantly altered, When
all these results are considered together, it seems unlikely that the anti
fertility and contraceptive efficacy of RICOM-1013-J is due to hormonal mec
hanisms alone since side effects, renal and liver function, and cholesterol
effects attributable to oestrogen and/or progesterone were minimal in the
volunteers. Copyright (C) 2000 John Wiley & Sons, Ltd.