Inhibition of nitric oxide release by an aqueous extract of Tinospora tuberculata

Authors
Yokozawa, T Wang, TS Chen, CP Hattori, M
Citation
T. Yokozawa et al., Inhibition of nitric oxide release by an aqueous extract of Tinospora tuberculata, PHYTOTHER R, 14(1), 2000, pp. 51-53
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHYTOTHERAPY RESEARCH
ISSN journal
0951418X → ACNP
Volume
14
Issue
1
Year of publication
2000
Pages
51 - 53
Database
ISI
SICI code
0951-418X(200002)14:1<51:IONORB>2.0.ZU;2-9
Abstract
An aqueous extract of Tinospora tuberculata stems was found to scavenge nit ric oxide (NO) in vitro in both cell and cell-free systems. When the aqueou s extract was added to lipopolysaccharide-stimulated murine macrophages, it inhibited NO release dose-dependently, and similar activity was found in a cell-free system using sodium nitroprusside as a NO donor. These findings may help to explain, in part, certain pharmacological activities of Tinospo ra tuberculata, Copyright (C) 2000 John Wiley & Sons, Ltd.