The lyophilized root decoction of Afrormosia laxiflora (Leguminosae), claim
ed to be beneficial in epilepsy and psychosis, was screened for depressant
and anticonvulsant activities using in vivo models. The root decoction, 150
-300 mg/kg, showed significant inhibition of motor activity in mice, indica
ting depressant actions. Similarly, doses of 150-300 mg/kg of this extract
significantly diminished the duration of convulsive symptoms, and increased
the seizure latency, in both picrotoxin- and electroshock-induced seizures
when compared with controls. The results suggest possible beneficial effec
ts of the plant's root and also offer a rational explanation for its folklo
re usage in epilepsy and related disorders. Copyright (C) 2000 John Wiley &
Sons, Ltd.