Depressant and anticonvulsant properties of the root decoction of Afrormosia laxiflora (Leguminosae)

The lyophilized root decoction of Afrormosia laxiflora (Leguminosae), claim ed to be beneficial in epilepsy and psychosis, was screened for depressant and anticonvulsant activities using in vivo models. The root decoction, 150 -300 mg/kg, showed significant inhibition of motor activity in mice, indica ting depressant actions. Similarly, doses of 150-300 mg/kg of this extract significantly diminished the duration of convulsive symptoms, and increased the seizure latency, in both picrotoxin- and electroshock-induced seizures when compared with controls. The results suggest possible beneficial effec ts of the plant's root and also offer a rational explanation for its folklo re usage in epilepsy and related disorders. Copyright (C) 2000 John Wiley & Sons, Ltd.