Fragments of a proline-rich polypeptide settled on a hexapeptide carcass constructed of glycine and L-lysine residues. Synthesis and biological properties

Authors
Wirkus-Romanowska, I Miecznikowska, H Zablocka, A Rybka, K Fortuna, W Miedzybrodzki, R Szymaniec, S Janusz, M Lisowski, J Kupryszewski, G
Citation
I. Wirkus-romanowska et al., Fragments of a proline-rich polypeptide settled on a hexapeptide carcass constructed of glycine and L-lysine residues. Synthesis and biological properties, POL J CHEM, 74(2), 2000, pp. 219-225
Citations number
20
Categorie Soggetti
Chemistry
Journal title
POLISH JOURNAL OF CHEMISTRY
ISSN journal
01375083 → ACNP
Volume
74
Issue
2
Year of publication
2000
Pages
219 - 225
Database
ISI
SICI code
0137-5083(200002)74:2<219:FOAPPS>2.0.ZU;2-#
Abstract
Proline-rich polypeptide fragments settled on a hexapeptide constructed of L-lysine and glycine residues were synthesized by the solid phase method: X -Lys(X)-Gly-Lys(X)-Gly-Lys(X)-Gly-OH, X = Tyr-Val-Pro-Leu-Phe-Pro and Y-Lys (Y)-Gly-Lys(Y)-Gly-Lys(Y)-Gly-OH, Y = Val-Glu-Ser-Tyr-Val-Pro-Leu-Phe-Pro. Immunotropic activity of the analogues was determined in a murine system us ing resistance to hydrocortisone and in human cell cultures using induction of cytokines as indicators.