A. Schellen et al., High throughput on-line solid phase extraction/tandem mass spectrometric determination of paclitaxel in human serum, RAP C MASS, 14(4), 2000, pp. 230-233
The feasibility of high throughput on-line solid phase extraction/tandem ma
ss spectrometry (SPE/MS/MS) is tested for target analysis of paclitaxel in
human serum, The use of a dual Prospekt system, with parallel SPE and eluti
on directly to the mass spectrometer, resulted in a cycle time of 80 second
s for the entire, fully automated assay. The assay proved to be linear from
1 to 1000 ng/mL, Cartridges packed with small sorbent particles functioned
both as SPE cartridges and as short analytical columns. Copyright (C) 2000
John Wiley & Sons, Ltd.