High throughput on-line solid phase extraction/tandem mass spectrometric determination of paclitaxel in human serum

Authors
Schellen, A Ooms, B van Gils, M Halmingh, O van der Vlis, E van de Lagemaat, D Verheij, E
Citation
A. Schellen et al., High throughput on-line solid phase extraction/tandem mass spectrometric determination of paclitaxel in human serum, RAP C MASS, 14(4), 2000, pp. 230-233
Citations number
9
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
ISSN journal
09514198 → ACNP
Volume
14
Issue
4
Year of publication
2000
Pages
230 - 233
Database
ISI
SICI code
0951-4198(2000)14:4<230:HTOSPE>2.0.ZU;2-C
Abstract
The feasibility of high throughput on-line solid phase extraction/tandem ma ss spectrometry (SPE/MS/MS) is tested for target analysis of paclitaxel in human serum, The use of a dual Prospekt system, with parallel SPE and eluti on directly to the mass spectrometer, resulted in a cycle time of 80 second s for the entire, fully automated assay. The assay proved to be linear from 1 to 1000 ng/mL, Cartridges packed with small sorbent particles functioned both as SPE cartridges and as short analytical columns. Copyright (C) 2000 John Wiley & Sons, Ltd.