Amniotic fluid embolism: a case report and review

A 41-year old primigravida underwent caesarean section because of foetal di stress following prostin induction of labour. Intraoperative coagulopathy, haemorrhage and hypotension necessitated a hysterectomy. Subsequently, she developed respiratory and renal failure, requiring mechanical ventilation a nd haemodialysis. She made a full recovery. The likely diagnosis was amniot ic fluid embolism (AFE), a rare complication of pregnancy with a variable p resentation, ranging from cardiac arrest and death through to mild degrees of organ system dysfunction with or without coagulopathy. The differential diagnosis includes pre-eclamptic toxaemia/pregnancy-induced hypertension, a naphylaxis and pulmonary embolism. There is no diagnostic test for AFE; the finding of foetal elements in the maternal circulation is non-specific. Hi storically, AFE was thought to induce cardiovascular collapse by mechanical obstruction of the pulmonary circulation. It is now thought that a combina tion of left ventricular dysfunction and acute lung injury occur, with acti vation of several of the clotting factors. An immunological basis for these effects is postulated. There is no specific therapy and treatment is suppo rtive. The mortality of the condition remains high. (C) 2000 Elsevier Scien ce Ireland Ltd. All rights reserved.