Cystic fibrosis (CF) is characterized by symptoms related to pulmonary dysf
unction and pancreatic insufficiency. Constipation, though a frequent compl
aint of patients with CF, receives less attention. We report a case of acqu
ired segmental megacolon and constipation necessitating surgical colonic re
section in an adult patient with CF. The differential diagnosis and possibl
e causes of megacolon in this setting are discussed.