Peculiarities of cell reception in bronchial asthma patients with bronchial hyperreactivity to hyperosmolar provocation

Aim. To investigate characteristics of the cell receptor systems in bronchi al asthma (BA) patients with bronchial hyperreactivity (BHR) induced by hyp erosmolar provocation. Materials and methods. 15 patients with BA, in most cases atopic, in remiss ion were studied. The bronchoprovocative test (BPT) with ultrasonically neb ulized 3.6% hypertonic NaCl solution (UNHS) FEV1-control was performed Cell receptors reactivity was analysed on the model of erythrocyte resistance ( ER) to hyperosmolar provocation (HP) under the modulation by adrenergic and histaminergic agents. Results. It was revealed that ER was significantly higher (p<0.05) in BA pa tients with BHR to UNHS under histaminergic modulation, but ER did not diff er in BA patients with or without BHR to UNHS under the adrenergic modulati on. The correlation was found between DFEV1 on BPT and magnitude of ER to H P under the blockade of H1-histaminergic receptors (r=0.72; p<0.02). Conclusion. The development of BHR to hyperosmolar stimulus may be due prim arily to disturbance of histaminergic receptor system.