Synthesis of new benzo-substituted macrocyclic ligands containing pyridineor triazole as subcyclic units

The macrocyclic diamides 11-21, 42 and 43 were prepared by nucleophilic rea ction of the bis phenols 22-29 with the appropriate dihalo compounds 2, 3, 40 and 41, respectively. The macrocyclic dithiodiamides 30-33 were obtained in good yields upon treatment of 11, 13, 15 and 17 with Lawesson's reagent . The macrocycles 61-63 were prepared by condensation of the bis(aldehyde) 37 with the appropriate bis(aminotriazoles) 50-54 to give the corresponding Schiff bases 56-60 followed by NaBH4 reduction. (C) 2000 Elsevier Science Ltd. All rights reserved.