alpha-Chloroacetyl capping of peptides: an N-terminal capping strategy suitable for Edman sequencing

Authors
Shogren-Knaak, MA McDonnell, KA Imperiali, B
Citation
Ma. Shogren-knaak et al., alpha-Chloroacetyl capping of peptides: an N-terminal capping strategy suitable for Edman sequencing, TETRAHEDR L, 41(6), 2000, pp. 827-829
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
6
Year of publication
2000
Pages
827 - 829
Database
ISI
SICI code
0040-4039(20000205)41:6<827:ACOPAN>2.0.ZU;2-3
Abstract
Use of an alpha-chloroacetyl group allows for the conditional N-terminal ca pping of peptides. This capping group is easily introduced and stable over a broad pH range, but can be converted to glycine by aqueous ammonia treatm ent in order to perform N-terminal Edman peptide sequencing. (C) 2000 Elsev ier Science Ltd. All rights reserved.