Citation
Dj. Silva et Mj. Sofia, Novel carbohydrate scaffolds. Assembly of a uridine-mannose scaffold basedon tunicamycin, TETRAHEDR L, 41(6), 2000, pp. 855-858
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039
→ ACNP
Volume
41
Issue
6
Year of publication
2000
Pages
855 - 858
Database
ISI
SICI code
0040-4039(20000205)41:6<855:NCSAOA>2.0.ZU;2-C
Abstract
A disaccharide scaffold based on tunicamycin was synthesized from D-uridine
and L-mannose. The key step in disaccharide assembly was a B-mannosylation
performed using Crich's modification of the sulfoxide glycosylation method
. The scaffold described contains two orthogonal derivatization sites and w
ill be used in the search for novel biologically active compounds. (C) 2000
Elsevier Science Ltd. All rights reserved.