Jp. Boissel et al., Outline of the problem of therapeutic efficacy indices 4: Expression of efficacy when the underlying illness is chronic, THERAPIE, 54(5), 1999, pp. 519-523
In chronic illness, when death or a non-fatal event can occur at any time,
the current efficacy indices are no longer appropriate to express the effec
t of the treatment on the potential therapeutic objectives. The inappropria
teness is not dependent on the effect model. Clues for solutions are propos
ed.