B. Benaji et al., Compatibility study of 5-fluorouracil with PVC bags after repackaging intotwo types of infusion admixtures, THERAPIE, 54(5), 1999, pp. 659-663
The stability and compatibility of 5-fluorouracil (5-FU) in admixtures for
continuous intravenous infusion using PVC bags and administration sets were
studied. 5-fluorouracil was reconstituted and diluted to 1.8 mg/ml for inf
usion in polyvinyl chloride and glass containers, and to 1 mg/ml to 16 mg/m
l for storage in polyvinyl chloride bags containing 5 per cent dextrose or
0.9 per cent sodium chloride injections. Admixtures were stored at +4 degre
es C and with protection from light, for 7 days. Analyses were performed by
HPLC. No significant drug loss was observed during simulated infusions usi
ng PVC infusion bags and administration sets vs glass bottles and administr
ation sets, over an infusion period used in hospitals (24 h). The solution
stored at +4 degrees C with protection from light in PVC bags showed that a
t 1 mg/ml to 16 mg/ml, 5-fluorouracil was stable at least for 7 days in 0.9
per cent sodium chloride and 5 per cent dextrose.