Serum levels of coenzyme Q(10) in patients with multiple sclerosis

To elucidate whether serum coenzyme Q(10) levels are related with the risk for multiple sclerosis (MS) or are a marker for the activity of the disease , we compared serum levels of coenzyme Q(10) and the coenzyme Q(10)/cholest erol ratio, in 31 patients with MS (during exacerbations) and 19 matched co ntrols using a high performance liquid chromatography technique. The mean s erum coenzyme Q(10) levels and the coenzyme Q(10)/cholesterol ratio did not differ significantly between the 2 study groups. The values did not correl ate With age, age at onset, and duration of the disease. These results sugg est that serum coenzyme Q(10) concentrations are unrelated with the risk fo r MS and are not a useful marker of activity of the disease.