Choroidal Langerhans' cell histiocytosis

Purpose: To report a patient with choroidal Langerhans' cell histiocytosis. Methods: A solitary tumor was found in the left eye of a 49-year-old male w ho had no definite history of systemic disorders, but had observed visual d isturbances for a period of 1 month. Ultrasonography, fluorescein angiograp hy, and indocyanine green angiography were performed and the eyeball was en ucleated. We prepared the specimen for microscopic examinations. Results: Fluorescein angiographic findings of the lesion were mottled hyper fluorescence in the arteriovenous phase and strong hyperfluorescence in the late phase. Hypofluorescence in both early and late phases showed on indoc yanine green angiogram, The lesion of choroid was widely infiltrated by his tiocytes, though no extraocular invasion was found. Immunohistochemical stu dies including S-100 and CD 68 staining revealed characteristic features of Langerhans cell histiocytosis. Electron microscopic examination of the his tiocytes showed histiocytosis X body (Birbeck granule) in the cytoplasm and indented nucleus. Conclusion: We consider that this is a case of choroidal Langerhans' cell h istiocytosis with no evidence of systemic lesions.