BISPHOSPHONATES IN CLINICAL-PRACTICE

Bisphosphonates are compounds with a high affinity for calcium-contain ing crystals. They inhibit osteoclast function. This has lead to their use in disorders characterized by increased bone resorption, such as osteoporosis, Paget's disease, certain forms of hypercalcemia, myeloma , and metastatic solid tumors. Bisphosphonates are available in both o ral and intravenous forms. Gastrointestinal toxicity and mineralizatio n defects are concerns with some forms of bisphosphonates. This articl e will review both currently ap proved and potential uses for bisphosp honates.