UNUSUAL PRESENTATION OF A PATIENT WITH CUSHINGS-DISEASE

Approximately 10% of pituitary tumors are plurihormonal, most of them silent from an endocrine point of view. We report here the case of a w oman with a bihormonal adenoma who presented with Cushing's disease. T he patient had a previous history of galactorrhea-amenorrhea and had b een submitted to hypophysectomy. Immunohistochemistry of the adenomato us tissue revealed the presence of ACTH- and PRL-secreting cells. Seve n years later, signs and symptoms of Gushing's syndrome developed. A s econd surgical intervention revealed corticotroph hyperplasia in the r emaining pituitary tissue. This uncommon course expands the spectrum o f presentation of pituitary adenomas.