RATIONAL DESIGN OF NEMATODE VACCINES - HIDDEN ANTIGENS

Hidden antigens are defined and the general validity of the hidden ant igen approach is considered. Approaches to the problem of identifying hidden antigens are offered. The nature of the immune responses induce d by injection of hidden antigens and their value in giving protection is considered in the Light of the site of the hidden antigen in vivo. Particular attention is given to the value of integral membrane ectoe nzymes as protective hidden antigens. The need to generate hidden anti gens as recombinant proteins and the possibilities and problems associ ated with linear, conformational and carbohydrate epitopes are outline d. Finally, concerns about the lack of stimulation of induced immune r esponses and the risks of resistance developing are addressed. (C) 199 7 Australian Society for Parasitology. Published by Elsevier Science L td.