Kc. Maki et al., Association between elevated plasma fibrinogen and the small, dense low-density lipoprotein phenotype among postmenopausal women, AM J CARD, 85(4), 2000, pp. 451-456
Citations number
19
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
A predominance of small, dense low-density lipoprotein (LDL) particles (sub
class pattern B) has been associated with a 2- to threefold increase in cor
onary heart disease risk. Recently, it has been reported that LDL subclass
pattern B is associated with hyperfibrinogenemia, which is also a coronary
heart disease risk factor. The present study examined the relation between
hyperfibrinogenemia and LDL subclass pattern in 258 postmenopausal women. A
significant univariate correlation was observed between the concentration
of cholesterol carried in small, dense LDL particles and plasma fibrinogen
concentration (r = 0.17, p = 0.01). The prevalence of LDL subclass pattern
B was 41.9% in the highest fibrinogen tertile, compared with 27.9% and 24.4
% in the first and second tertiles, respectively (global chi-square 6.8, p
= 0.03). The crude odds ratio (OR) for LDL subclass pattern B among women i
n the highest fibrinogen tertile, compared with the lower tertiles, was 2.0
3 (95% confidence interval [CI] 1.18 to 3.51, p = 0.01). After adjustment f
or age and plasma lipids (log, triglycerides, LDL cholesterol, and high-den
sity lipoprotein cholesterol), the OR was 2.14 (95% CI 1.17 to 3.96, p = 0.
01). Further adjustment for hematocrit, indicators of carbohydrate homeosta
sis, body mass index, waist circumference, and several variables related to
lifestyle did not attenuate this association (OR 2.56, 95% CI 1.27 to 5.27
, p = 0.01). These data suggest that hyperfibrinogenemia and LDL subclass p
attern B may be 2 components of a common syndrome and suggest that hyperfib
rinogenemia may contribute to the increased coronary heart disease risk ass
ociated with LDL subclass pattern B. (C) 2000 by Excerpta Medica, Inc.