Declining prevalence of opportunistic gastrointestinal disease in the era of combination antiretroviral therapy

OBJECTIVE: Opportunistic disorders (OD) are the most frequent GI manifestat ions of the acquired immunodeficiency syndrome (AIDS). Since the introducti on of highly active antiretroviral therapy (HAART), there appears to be hav e been a reduction in the incidence of many of these OD; however, the effec t of HAART on the prevalence of GI OD has not been well studied. METHODS: From 4/95 through 3/98, all HIV (HIV)-infected patients undergoing GI endoscopy were prospectively identified; mucosal biopsies were obtained in a standardized fashion and histological specimens were examined by a si ngle GI pathologist. Patients were divided into three groups based on the t ime of evaluation: group I: 4/95 to 3/96; group II: 4/96 to 3/97; and group III: 4/97 to 3/98. RESULTS: A total of 166 patients (90% men; mean age 36 +/- 10 yr; median CD 4 lymphocyte count 62 cells/mu l, range 2-884, median viral RNA level 1,357 copies/ml, range undetectable to 7,721,715) underwent 279 upper and/or low er endoscopies during the study period. There were no statistical differenc es in patients' demographics and indications for endoscopy although the CD 4 lymphocyte count was higher in group III. The percentage of patients rece iving HAART at the time of endoscopy increased from 0% to 57% over the thre e periods (p < 0.01), and the percentage of patient receiving combination a ntiretroviral therapy increased from 37% to 82% over the study period (p < 0.01). In contrast, the prevalence of OD decreased from 69% (group I) to 13 % (group III) (p < 0.01), whereas the prevalence of non-OD, including a nor mal endoscopy increased from 31% to 87% (p < 0.01). CONCLUSIONS: GI OD now seem to be an uncommon problem in HIV-infected patie nts undergoing endoscopy despite a low CD4 lymphocyte count, and this reduc tion of OD was associated with the use of HAART. (C) 2000 by Am. Cell. of G astroenterology.