F. Gloria-bottini et al., Adenosine deaminase-acid phosphatase association and the environment: A study in a continental Italian population, AM J HUM B, 12(2), 2000, pp. 214-220
Citations number
32
Categorie Soggetti
Sociology & Antropology","Medical Research General Topics
Three hundred fifty newborns from Rome and 351 from Penne were studied in c
ontinental Italy. Medium high altitude above sea level and cold winters cha
racterize the area of Penne, while low altitude and very mild winters chara
cterize the area of Rome. An effect of environmental conditions on the asso
ciation between adenosine deaminase (ADA) and acid phosphatase (ACP1), prev
iously shown in Sardinia, has been confirmed in continental Italy. When com
pared with expected independent assortment, the proportion of ACP1*A/*A car
rying the ADA*2 allele is lower than expected in the lowlands and higher th
an expected in highlands. In continental Italy there is an interaction amon
g ACP1-ADA genotype, season of conception, and locality. The excess of *A/*
A newborns carrying the ADA*2 allele is present only among those conceived
in the first half of the year (January-June). Among newborns in Penne conce
ived in the Spring, the proportion of those with *A/*A genotype is increase
d and these infants show decreased intrauterine growth, The present data su
ggest that ADA and ACP1 interact during intrauterine life with effects on d
evelopment and survival and that such effects are dependent on local enviro
nment and season of conception. (C) 2000 Wiley-Liss, Inc.