Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics

Citation
D. Grenier et al., Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics, ANTIM AG CH, 44(3), 2000, pp. 763-766
Citations number
29
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
3
Year of publication
2000
Pages
763 - 766
Database
ISI
SICI code
0066-4804(200003)44:3<763:IAOTAI>2.0.ZU;2-W
Abstract
Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. De termination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly i nfluenced by the presence of an excess of iron that likely saturates the an tibiotic. On the other hand, the MICs of doxycycline and minocycline were s ignificantly lower for A. actinomycetemcomitans cultivated under iron-poor conditions than under iron-rich conditions.