Intravitreal, retinal, and central nervous system foscarnet concentrationsafter rapid intravenous administration to rabbits

Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet lev els were measured by highperformance liquid chromatography after administra tion of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rab bits. A pharmacokinetic analysis was done using a two-compartment model. Th e penetration ratios, defined as ratios of retinal, vitreous humor, brain, and CSF areas under the concentration-time curve from 0 to 2 h were 110% +/ - 1%, 12.3% +/- 0.7%, 118% +/- 1%, and 20.2% +/- 2.2%, respectively. These results suggest a good penetration of foscarnet into the retinal and brain tissues, reaching higher concentrations than those estimated from vitreous humor and CSF levels.