Antiviral activity of 2 '-deoxy-3 '-oxa-4 '-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice

Authors
Stoddart, CA Moreno, ME Linquist-Stepps, VD Bare, C Bogan, MR Gobbi, A Buckheit, RW Bedard, J Rando, RF McCune, JM
Citation
Ca. Stoddart et al., Antiviral activity of 2 '-deoxy-3 '-oxa-4 '-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice, ANTIM AG CH, 44(3), 2000, pp. 783-786
Citations number
32
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
3
Year of publication
2000
Pages
783 - 786
Database
ISI
SICI code
0066-4804(200003)44:3<783:AAO2''>2.0.ZU;2-V
Abstract
Oral administration of 2' -deoxy-3' -oxa-4' -thiocytidine (BCH-10652), a nu cleoside analog structurally similar to lamivudine (3TC), caused dose-depen dent inhibition of viral replication in SCID-hu Thy/Liv mice infected with human immunodeficiency virus type 1 NL4-3 and with an NL4-3 clone containin g the M184V mutation in reverse transcriptase that confers resistance to 3T C. These experiments demonstrate the utility of this mouse model for evalua ting drug resistance and for performing direct comparisons between antivira l compounds in vivo.