Structure-activity relationship studies of chloromethyl ketone derivativesfor selective human chymase inhibitors

Authors
Hayashi, Y Iijima, K Katada, J Kiso, Y
Citation
Y. Hayashi et al., Structure-activity relationship studies of chloromethyl ketone derivativesfor selective human chymase inhibitors, BIOORG MED, 10(3), 2000, pp. 199-201
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
199 - 201
Database
ISI
SICI code
0960-894X(20000207)10:3<199:SRSOCK>2.0.ZU;2-8
Abstract
Based on the SAR study of a classical chloromethyl ketone derivative, Z-Phe CH(2)Cl 1, a series of compounds were synthesized. Among all the derivative s, compound 21 was found to be a potent human chymase inhibitor with no inh ibitory activity against human leukocyte cathepsin G. (C) 2000 Elsevier Sci ence Ltd. All rights reserved.