N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl] amines: Potent antagonists of human neuropeptide YY5 receptor

Authors
McNally, JJ Youngman, MA Lovenberg, TW Nepomuceno, DH Wilson, SJ Dax, SL
Citation
Jj. Mcnally et al., N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl] amines: Potent antagonists of human neuropeptide YY5 receptor, BIOORG MED, 10(3), 2000, pp. 213-216
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
213 - 216
Database
ISI
SICI code
0960-894X(20000207)10:3<213:NAPA>2.0.ZU;2-P
Abstract
[3a,4,5,9b-Tetrahydro-1H-benzo[e]indol-2-yl]amines were prepared via reduct ive amination and concomitant cyclization of alpha-cyanomethyl-beta-aminote tralins. N-acylation with Omega-sulfonamido-carboxylic acids and subsequent reduction afforded a series of N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e] indol-2-yl]amines, which bound to the human neuropeptide Y Y5 receptor with nanomolar affinity. (C) 2000 Elsevier Science Ltd. All rights reserved.