Structure-activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates - Systematic modification of peptide spacers

Authors
Nogusa, H Yano, T Kashima, N Yamamoto, K Okuno, S Hamana, H
Citation
H. Nogusa et al., Structure-activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates - Systematic modification of peptide spacers, BIOORG MED, 10(3), 2000, pp. 227-230
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
227 - 230
Database
ISI
SICI code
0960-894X(20000207)10:3<227:SROC>2.0.ZU;2-V
Abstract
A series of carboxymethylpullulan (CMPul)-doxorubicin (DXR) conjugates boun d by peptide spacers of different compositions and lengths were prepared an d evaluated for their in vivo antitumor effects. Systematic study of the pe ptide spacers indicated that CMPul-DXR conjugates bound via appropriate dip eptide spacers were more potent than DXR. (C) 2000 Elsevier Science Ltd. Al l rights reserved.