Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids

Authors
Parker, EJ Bello, CG Coggins, JR Hawkins, AR Abell, C
Citation
Ej. Parker et al., Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids, BIOORG MED, 10(3), 2000, pp. 231-234
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
231 - 234
Database
ISI
SICI code
0960-894X(20000207)10:3<231:MSOTIA>2.0.ZU;2-C
Abstract
(6R)- and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates fo r type I and type II dehydroquinases. Their differential reactivity provide s insight into details of the reaction mechanism and enables a novel enzyme -substrate imine to be trapped on the type I enzyme. (C) 2000 Elsevier Scie nce Ltd. All rights reserved.