Synthesis and evaluation of daunorubicin-paclitaxel dimers

Authors
Kar, AK Braun, PD Wandless, TJ
Citation
Ak. Kar et al., Synthesis and evaluation of daunorubicin-paclitaxel dimers, BIOORG MED, 10(3), 2000, pp. 261-264
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
261 - 264
Database
ISI
SICI code
0960-894X(20000207)10:3<261:SAEODD>2.0.ZU;2-Z
Abstract
Bifunctional, heterodimeric compounds were synthesized to test their abilit y to create polyvalent arrays between DNA and microtubules in cells. Each d imer was examined for the capacity to bind to microtubules and for cytotoxi city against MES-SA and MES-SA/Dx5 cell lines. (C) 2000 Elsevier Science Lt d. All rights reserved.