Synthesis of immunoreagents for detection of deoxypyrrololine, a cross-link of bone collagen

Authors
Adamczyk, M Johnson, DD Reddy, RE
Citation
M. Adamczyk et al., Synthesis of immunoreagents for detection of deoxypyrrololine, a cross-link of bone collagen, BIOORG MED, 10(3), 2000, pp. 269-271
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
269 - 271
Database
ISI
SICI code
0960-894X(20000207)10:3<269:SOIFDO>2.0.ZU;2-C
Abstract
Two immunogens (5,6) and two probes (fluorescent 7 and chemiluminescent 8) were prepared from benzyl ester (-)-10. These immunoreagents (5,6 and 7,8) are useful for detection of collagen cross-link (+)-deoxypyrrololine (Dpl, 4), and for development of assays for osteoporosis. (C) 2000 Elsevier Scien ce Ltd. All rights reserved.