3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors

Authors
Ding, CZ Hunt, JT Ricca, C Manne, V
Citation
Cz. Ding et al., 3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors, BIOORG MED, 10(3), 2000, pp. 273-275
Citations number
29
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
273 - 275
Database
ISI
SICI code
0960-894X(20000207)10:3<273:3ANSO>2.0.ZU;2-V
Abstract
Design, synthesis and structure-activity relationship of a series of 3-imid azolylmethylaminophenylsulfonyltetrahydroquinolines as farnesyltransferase inhibitors are presented. A working pharmacophore of inhibiting farnesyltra nsferase by this series of inhibitors is proposed. (C) 2000 Elsevier Scienc e Ltd. All rights reserved.